Regional differences in infection and structural lung disease in infants and young children with cystic ﬁbrosis
This study aimed to explore the links between infection and where early damage due to CF is found in young children with CF.
The results showed that the sites where infection, inflammation and lung damage occurred were often different. Our findings suggest that factors contributing to inflammation and lung damage other than early infection may be important in the earliest development of lung scarring.
This study highlights the complexity of early lung disease in CF and how much we still need to understand about the earliest infection, inflammation and lung damage.
Authors: Rosemary Carzino, Katherine B. Frayman, Louise King, Suzanna Vidmar, Sarath Ranganathan on behalf of AREST CF.
Published in the Journal of Cystic Fibrosis December 2019.