Skip to content

The past decade has seen significant advances in understanding of the pathogenesis and progression of lung disease in cystic fibrosis (CF). Pulmonary inflammation, infection, and structural lung damage manifest very early in life and are prevalent among preschool children and infants, often in the absence of symptoms or signs. Early childhood represents a pivotal period amenable to intervention strategies that could delay or prevent the onset of lung damage and alter the longer-term clinical trajectory for individuals with CF. This review summarizes what we have learned about early lung disease in children with CF and discusses the implications for future clinical practice and research.


Authors: Sarath C. Ranganathan, Graham L. Hall, Peter D. Sly, Stephen M. Stick, and Tonia A. Douglas on behalf of AREST CF.

Published in the American Journal of Respiratory and Critical Care Medicine in June 2017. 

Discover. Prevent. Cure.

Contact Telethon Kids

Telethon Kids Institute
Northern Entrance
Perth Children's Hospital
15 Hospital Avenue

T (08) 6319 1000

©2023 Telethon Kids Institute