Developing a pipeline for MRSA bacteriophage
Staphylococcus aureus (S. aureus), has gained a reputation for becoming resistant to antibiotics very quickly. Antibiotic resistant S. aureus is also known as MRSA (Methicillin-resistant Staphylococcus aureus) and is a major concern for people who are prone to bacterial infections including those with Cystic Fibrosis (CF).
Kids with CF commonly catch S. aureus respiratory tract infections which are treated with antibiotics throughout early life. With repeated infections, resistance develops which can lead to persistent MRSA infection which is known to drive permanent airway damage.
As part of the phage team at The Wal-yan Respiratory Research Centre we are establishing a pipeline for the isolation and characterisation of phages that can target MRSA bacteria from individuals with CF. This pipeline includes the isolation of phage from locally sourced environmental samples and their characterisation, including their size and dimension usually taken via transmission electron microscopy.